Virosomes for antigen and DNA delivery

摘要: Specific targeting and delivery as well the display of antigens on surface professional antigen-presenting cells (APCs) are key issues in design development new-generation vaccines aimed at induction both humoral cell-mediated immunity. Prophylactic vaccination against infectious diseases general aims immune responses to prevent infection. This response is mediated by antibody-producing B cells. On other hand, therapeutic immunisation virally infected tumour requires cytotoxic T lymphocytes (CTLs) that can specifically recognise lyse or transformed The Major Histocompatibility Complex (MHC) class I restricted CTL activity optimally achieved synthesis within APCs, for example, after with live attenuated virus. However, bears risk causing disease. Therefore, alternative vaccine systems, which enable introduction nonreplicating antigen into MHC presentation pathway, sought. Furthermore, effective cellular responses, II activation helper (Th cells) required. Among described this theme issue Advanced Drug Delivery Reviews, virosomes seem ideally suited pathways. In review, we will focus use carrier vehicles intracellular protein DNA, a encapsulated proteins expressed virosome-associated plasmids.