Ampakine (CX717) effects on performance and alertness during simulated night shift work.

摘要: Introduction: Round-the-clock operations in both military and civilian sectors have increased the need for alertness- performance-maintaining strategies. The potential performance objective alertness-enhancing effects of CX717 (a novel cognitive enhancer currently being tested Phase II clinical trials) were evaluated using a simulated night shift work paradigm. Methods: In this randomized, double-blind, placebo-controlled, parallel groups design, 48 volunteers underwent 4 consecutive nights work. Each "shift" consisted following: at approximately 2145 (just prior to start each shift), ingested single oral dose CX71 7 200 mg, 400 1000 or placebo (N = 12 per drug dosage). Performance, alertness, mood, symptoms then assessed from 2300 0700, followed by polysomnographically monitored daytime sleep period 0800 1200. Results: Performance alertness significantly degraded across shifts (P 0.05). exerted some on sleep, most notably reduction slow-wave time (P< caused very few side none those serious unexpected. Discussion Conclusions: At doses tested, was not effective reversing deficits associated with Further evaluating higher may be warranted, as are studies which explored under other conditions (e.g., Alzheimer's dementia, attention deficit disorder).