Carcinogen activation by sulfate conjugate formation.
作者： Christopher J. Michejda , Marilyn B. Kroeger Koepke
DOI: 10.1016/S1054-3589(08)61038-8
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摘要: Publisher Summary This chapter describes carcinogen activation by sulphate conjugate formation. It presents a substantial body of data establishing that sulfotransferase conjugation could transform many xenobiotics into agents for modifying cellular macromolecules. However, sulfation is rarely the only metabolic pathway open to these compounds; other pathways can become more important in response variety factors. switching be produced substrate concentration, cofactor availability, kinetic factors dictate velocity various possible reactions, and, some cases, competition between Phase-I and Phase-II metabolism. In addition, it realize demonstration sulfate ester formation vitro does not necessarily mean similar process occur vivo. experience also teaches argument analogy very misleading case activation. Small structural differences upset delicate balance competing pathways. Sulfation an mechanism which number chemicals are transformed their activated forms.
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