The Association of Systemic Microvascular Changes with Lung Function and Lung Density: A Cross-Sectional Study

摘要: Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes heart. Little is known about changes smoking-related lung disease. We tested if retina, kidneys heart were associated obstructive spirometry low density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45-84 years without clinical cardiovascular Measures function included retinal arteriolar venular caliber, urine albumin-to-creatinine ratio and, a subset, myocardial blood flow magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) fields cardiac tomograms. Regression models adjusted for pulmonary risk factors, medications body size. Among 3,397 participants, caliber inversely forced expiratory volume one second (FEV(1)) (P<0.001) FEV(1)/forced vital capacity (FVC) (P = 0.04). Albumin-to-creatinine FEV(1) (P = 0.002) but not FEV(1)/FVC. Myocardial (n = 126) lower (P = 0.02), FEV(1)/FVC (P = 0.001) greater percentage LAA Associations magnitude among smokers. heart, impaired perfusion. These cross-sectional results suggest that all circulations may pertain to lung, contribute disease, or there be shared predisposition.