Pharmacogenetics in Clinical and Forensic Toxicology: Opioid Overdoses and Deaths
作者： Saeed A. Jortani , Elaine Stauble , Steven H. Wong
DOI: 10.1007/978-1-61779-222-9_1
关键词:
摘要: Factors considered in the observed variability drug response within a population are intrinsic, extrinsic, or combination of both. The intrinsic factors differences demographics given individual (e.g., age gender), disease physical condition renal function BMI), and pharmacogenetics (see below). extrinsic composed environmental diet) as well interactions polypharmacy.
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Steven H. Wong, Michael A. Wagner, Jeffrey M. Jentzen, Chuck Schur, Jeanette Bjerke, Susan B. Gock, Chung-Che Chang, Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity? Journal of Forensic Sciences. ,vol. 48, pp. 1406- 1415 ,(2003) , 10.1520/JFS2002392
S Gesell, P Lanser, Pain management: the fifth vital sign Healthcare benchmarks. ,vol. 8, pp. 68- ,(2001)
Michael R. Langley, Jessica K. Booker, James P. Evans, Howard L. McLeod, Karen E. Weck, Validation of Clinical Testing for Warfarin Sensitivity The Journal of Molecular Diagnostics. ,vol. 11, pp. 216- 225 ,(2009) , 10.2353/JMOLDX.2009.080123
Werner Scheithauer, Alois Lang, Thomas Winder, K-ras mutations and cetuximab in colorectal cancer. The New England Journal of Medicine. ,vol. 360, pp. 834- 834 ,(2009)
Mark R. Hutchinson, Andrew Menelaou, David J. R. Foster, Janet K. Coller, Andrew A. Somogyi, CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes British Journal of Clinical Pharmacology. ,vol. 57, pp. 287- 297 ,(2003) , 10.1046/J.1365-2125.2003.02002.X
Jose de Leon, Margaret T. Susce, Maria Johnson, Mike Hardin, Lorraine Maw, Alison Shao, Antonette C.P. Allen, Francis A. Chiafari, Grantland Hillman, D. Michele Nikoloff, DNA Microarray Technology in the Clinical Environment: The AmpliChip CYP450 Test for CYP2D6 and CYP2C19 Genotyping CNS Spectrums. ,vol. 14, pp. 19- 35 ,(2009) , 10.1017/S1092852900020022
Takashi Iyanagi, Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification. International Review of Cytology-a Survey of Cell Biology. ,vol. 260, pp. 35- 112 ,(2007) , 10.1016/S0074-7696(06)60002-8
Vincent KF Kong, Michael G Irwin, Adjuvant analgesics in neuropathic pain. European Journal of Anaesthesiology. ,vol. 26, pp. 96- 100 ,(2009) , 10.1097/EJA.0B013E328318C706
Marie M. Ahlström, Marianne Ridderström, Ismael Zamora, CYP2C9 Structure−Metabolism Relationships: Substrates, Inhibitors, and Metabolites Journal of Medicinal Chemistry. ,vol. 50, pp. 5382- 5391 ,(2007) , 10.1021/JM070745G
Yvan Gasche, Youssef Daali, Marc Fathi, Alberto Chiappe, Silvia Cottini, Pierre Dayer, Jules Desmeules, Codeine intoxication associated with ultrarapid CYP2D6 metabolism. The New England Journal of Medicine. ,vol. 351, pp. 2827- 2831 ,(2004) , 10.1056/NEJMOA041888