MiR‐214 reduces cell survival and enhances cisplatin‐induced cytotoxicity via down‐regulation of Bcl2l2 in cervical cancer cells
作者： Fang Wang , Min Liu , Xin Li , Hua Tang
DOI: 10.1016/J.FEBSLET.2013.01.016
关键词:
摘要: MiR-214 has been shown to inhibit cell growth, migration and invasion. Here we demonstrate that ectopic expression of miR-214 reduces survival, induces apoptosis enhances sensitivity cisplatin through directly inhibiting Bcl2l2 in cervical cancer HeLa C-33A cells. Further analysis reveals induced by is correlated with increased Bax, caspase-9, caspase-8 caspase-3. Moreover, show regulated DNA methylation histone deacetylation. Taken together, these data suggest might be a candidate target for the development novel therapeutic strategies treat cancer.
core.ac.uk
sci-hub.se 参考文章(26)
Shaun P. Holmgreen, Suzanne Cory, Elizabeth Baker, Leonie Gibson, Jerry M. Adams, Nancy A. Jenkins, Neal G. Copeland, Grant R. Sutherland, David C.S. Huang, Ora Bernard, bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene. ,vol. 13, pp. 665- 675 ,(1996)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
J W Wilson, M C Nostro, M Balzi, P Faraoni, F Cianchi, A Becciolini, C S Potten, Bcl-w expression in colorectal adenocarcinoma British Journal of Cancer. ,vol. 82, pp. 178- 185 ,(2000) , 10.1054/BJOC.1999.0897
Zuozhen Yang, Shuang Chen, Xuejing Luan, Yixuan Li, Min Liu, Xin Li, Tao Liu, Hua Tang, MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells. Iubmb Life. ,vol. 61, pp. 1075- 1082 ,(2009) , 10.1002/IUB.252
Taeko Wada, Jiro Kikuchi, Yusuke Furukawa, Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8 EMBO Reports. ,vol. 13, pp. 142- 149 ,(2012) , 10.1038/EMBOR.2011.247
Yanmin Xu, Feng Xia, Leina Ma, Juanjuan Shan, Junjie Shen, Zhi Yang, Jia Liu, Youhong Cui, Xiuwu Bian, Ping Bie, Cheng Qian, MicroRNA-122 sensitizes HCC cancer cells to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest Cancer Letters. ,vol. 310, pp. 160- 169 ,(2011) , 10.1016/J.CANLET.2011.06.027
Igor B. Roninson, The role of the MDR1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo Biochemical Pharmacology. ,vol. 43, pp. 95- 102 ,(1992) , 10.1016/0006-2952(92)90666-7
Lin Xia, Dexin Zhang, Rui Du, Yanglin Pan, Lina Zhao, Shiren Sun, Liu Hong, Jie Liu, Daiming Fan, miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. International Journal of Cancer. ,vol. 123, pp. 372- 379 ,(2008) , 10.1002/IJC.23501
Mahmood Manavi, Gernot Hudelist, Anneliese Fink-Retter, Daphne Gschwandtler-Kaulich, Kerstin Pischinger, Klaus Czerwenka, Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma. Gynecologic Oncology. ,vol. 105, pp. 418- 426 ,(2007) , 10.1016/J.YGYNO.2006.12.032
Ran Qiang, Fang Wang, Li-Ying Shi, Min Liu, Shuang Chen, Hai-Ying Wan, Yi-Xuan Li, Xin Li, Song-Yuan Gao, Bao-Cun Sun, Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells The International Journal of Biochemistry & Cell Biology. ,vol. 43, pp. 632- 641 ,(2011) , 10.1016/J.BIOCEL.2011.01.002