First biosynthetic evidence on the phenyl-containing polyketides of the marine mollusc Scaphander lignarius.
作者： Adele Cutignano , Conxita Avila , Anna Domenech-Coll , Giuliana d’Ippolito , Guido Cimino
DOI: 10.1021/OL800877F
关键词:
摘要: The biosynthesis of lignarenones 1 and 2, the major polyketides Mediterranean mollusc Scaphander lignarius is described. process primed by benzoic acid requires acetate propionate as extender units. labeling pattern suggests PKS-like synthesis an unusual E,Z,E-triene chain origin benzoate unit from phenylalanine. 13C-13C NMR COSY has been used to establish positions due incorporation 13C2-acetate.
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