NO to cancer: The complex and multifaceted role of nitric oxide and the epigenetic nitric oxide donor, RRx-001.
作者： Jan Scicinski , Bryan Oronsky , Shoucheng Ning , Susan Knox , Donna Peehl
DOI: 10.1016/J.REDOX.2015.07.002
关键词:
摘要: … Herein we discuss the multiple effects of NO and focus on the clinical molecule RRx-001, a … Left: schematic of reduction of serum nitrite to nitric oxide by RRx-001-bound hemoglobin. …
core.ac.uk
elsevier.com
sci-hub.se 参考文章(71)
Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams, William L. Fitch, Preclinical evaluation of the metabolism and disposition of RRx-001, a novel investigative anticancer agent. Drug Metabolism and Disposition. ,vol. 40, pp. 1810- 1816 ,(2012) , 10.1124/DMD.112.046755
Shoucheng Ning, Junqiang Tian, Deborah J. Marshall, Susan J. Knox, Anti–αv Integrin Monoclonal Antibody Intetumumab Enhances the Efficacy of Radiation Therapy and Reduces Metastasis of Human Cancer Xenografts in Nude Rats Cancer Research. ,vol. 70, pp. 7591- 7599 ,(2010) , 10.1158/0008-5472.CAN-10-1639
Xiaohuan Gao, Debabrata Saha, Payal Kapur, Thomas Anthony, Edward H. Livingston, Sergio Huerta, Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate Journal of Surgical Oncology. ,vol. 100, pp. 149- 158 ,(2009) , 10.1002/JSO.21318
Bénédicte F Jordan, Pierre-Damien Misson, Roger Demeure, Christine Baudelet, Nelson Beghein, Bernard Gallez, Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI. International Journal of Radiation Oncology Biology Physics. ,vol. 48, pp. 565- 570 ,(2000) , 10.1016/S0360-3016(00)00694-5
Peter Wardman, Kai Rothkamm, Lisa K. Folkes, Michael Woodcock, Peter J. Johnston, Radiosensitization by Nitric Oxide at Low Radiation Doses Radiation Research. ,vol. 167, pp. 475- 484 ,(2007) , 10.1667/RR0827.1
Quan-Sing Ng, Vicky Goh, Jessica Milner, Michael R Stratford, Lisa K Folkes, Gillian M Tozer, Michele I Saunders, Peter J Hoskin, Effect of nitric-oxide synthesis on tumour blood volume and vascular activity: a phase I study Lancet Oncology. ,vol. 8, pp. 111- 118 ,(2007) , 10.1016/S1470-2045(07)70001-3
Louis Harrison, Kimberly Blackwell, Hypoxia and Anemia: Factors in Decreased Sensitivity to Radiation Therapy and Chemotherapy? Oncologist. ,vol. 9, pp. 31- 40 ,(2004) , 10.1634/THEONCOLOGIST.9-90005-31
Larry K. Keefer, James Liebmann, David Venzon, David A. Wink, Anne Marie DeLuca, James B. Mitchell, Deborah Coffin, In Vivo Radiation Protection by Nitric Oxide Modulation Cancer Research. ,vol. 54, pp. 3365- 3368 ,(1994)
Pierre Sonveaux, Irina I. Lobysheva, Olivier Feron, Timothy J. McMahon, Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery. Physiology. ,vol. 22, pp. 97- 112 ,(2007) , 10.1152/PHYSIOL.00042.2006
Barry W. Allen, Claude A. Piantadosi, How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm American Journal of Physiology-heart and Circulatory Physiology. ,vol. 291, ,(2006) , 10.1152/AJPHEART.00310.2006