Diverse functions of the prion protein - Does proteolytic processing hold the key?

摘要: Proteolytic processing of the cellular and disease-associated form prion protein leads to generation bioactive soluble fragments modifies structure function its cell-bound form. The nature proteases responsible for shedding, α-, β-, γ-cleavage are only partially identified their regulation is largely unknown. Here, we provide an overview increasingly multifaceted picture proteolysis shed light on physiological pathological roles associated with these cleavages. This article part a Special Issue entitled: Proteolysis as Regulatory Event in Pathophysiology edited by Stefan Rose-John.