Novel hydrophilic galactose-conjugated chlorin e6 derivatives for photodynamic therapy and fluorescence imaging.

摘要: Abstract We synthesized new hydrophilic chlorin e6 derivatives with two and four galactose fragments conjugated to the macrocycle via carbon atom in position 6 of fragment. Galactose were inserted by alkylation amino groups amides one ethylene diamine on periphery triflate diacetone galactose, followed removal diisopropylidene protection 70% aqueous trifluoroacetic acid. The compounds shown be capable penetrating membrane HeLa cells; they have intense red fluorescence inside cell phototoxic properties towards cells (upon LED irradiation at 660 nm light exposure value 12 J/cm2). These properties, along water solubility, allow us consider promising as potential antitumor PSs diagnostic for visualizing malignant tumors creating their basis preparations simultaneous diagnostics therapy oncological diseases.