Radix Achyranthis Bidentatae improves learning and memory capabilities in ovariectomized rats.
作者： Yanshu Pan , Weihong Li , Wei Zhang , Jing Jia , Ya Xu
DOI: 10.3969/J.ISSN.1673-5374.2013.18.002
关键词:
摘要: Kidney-tonifying recipe can reduce the accumulation of advanced glycation end products, prevent neuronal degeneration and improve cognitive functions in ovariectomized rats. Radix Achyranthis Bidentatae alcohol extracts may dose-dependently inhibit non-enzymatic saccharification vitro. This study aimed to examine effect on products learning memory capabilities Ovariectomized rats were treated with (containing 1.5 g/kg crude drug) or 0.1% aminoguanidine for 12 weeks behavioral testing was performed Y-electrical maze. test revealed that could Results competitive enzyme-linked immunosorbent assay showed treatment reduced frontal cortex rats, while increasing content blood urine. Biochemical tests decreased superoxide dismutase activity serum cortex, increased levels glutathione peroxidase In addition, there no apparent malondialdehyde levels. These experimental findings indicate inhibits production its brain tissue, improves effects be associated an anti-oxidative action extract.
nrronline.org参考文章(59)
Jia Yao, Roberta Diaz Brinton, Estrogen Regulation of Mitochondrial Bioenergetics: Implications for Prevention of Alzheimer’s Disease Advances in pharmacology (San Diego). ,vol. 64, pp. 327- 371 ,(2012) , 10.1016/B978-0-12-394816-8.00010-6
S Horiuchi, N Araki, Y Morino, Immunochemical approach to characterize advanced glycation end products of the Maillard reaction. Evidence for the presence of a common structure. Journal of Biological Chemistry. ,vol. 266, pp. 7329- 7332 ,(1991) , 10.1016/S0021-9258(20)89449-6
Hari Shanker Sharma, Rudy J. Castellani, Mark A. Smith, Aruna Sharma, The blood-brain barrier in Alzheimer's disease: novel therapeutic targets and nanodrug delivery. International Review of Neurobiology. ,vol. 102, pp. 47- 90 ,(2012) , 10.1016/B978-0-12-386986-9.00003-X
Chun Liang, Yusheng Ren, Hongbin Tan, Zhiqing He, Qijun Jiang, Jianxiang Wu, Yi Zhen, Min Fan, Zonggui Wu, Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products. British Journal of Pharmacology. ,vol. 158, pp. 1865- 1873 ,(2009) , 10.1111/J.1476-5381.2009.00450.X
Jose Luis Herrera, Cecilia Fernandez, Mario Diaz, Debora Cury, Raquel Marin, None, Estradiol and tamoxifen differentially regulate a plasmalemmal voltage-dependent anion channel involved in amyloid-beta induced neurotoxicity. Steroids. ,vol. 76, pp. 840- 844 ,(2011) , 10.1016/J.STEROIDS.2011.02.014
Chun Shi, Juntao Zou, Guoying Li, Zhenying Ge, Zhibin Yao, Jie Xu, Bilobalide protects mitochondrial function in ovariectomized rats by up-regulation of mRNA and protein expression of cytochrome c oxidase subunit I. Journal of Molecular Neuroscience. ,vol. 45, pp. 69- 75 ,(2011) , 10.1007/S12031-010-9388-Z
Kyunghee Byun, Enkhjaigal Bayarsaikhan, Daesik Kim, Chae Young Kim, Inhee Mook-Jung, Sun Ha Paek, Seung U. Kim, Tadashi Yamamoto, Moo-Ho Won, Byoung-Joon Song, Young Mok Park, Bonghee Lee, Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer's disease. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0037917
Shun-Yao Ko, Yi-Pai Lin, Yi-Shiuan Lin, Shu-Shing Chang, Advanced glycation end products enhance amyloid precursor protein expression by inducing reactive oxygen species Free Radical Biology and Medicine. ,vol. 49, pp. 474- 480 ,(2010) , 10.1016/J.FREERADBIOMED.2010.05.005
Takashi Sato, Noriko Shimogaito, Xuegang Wu, Seiji Kikuchi, Sho-ichi Yamagishi, Masayoshi Takeuchi, Toxic Advanced Glycation End Products (TAGE) Theory in Alzheimer’s Disease American Journal of Alzheimers Disease and Other Dementias. ,vol. 21, pp. 197- 208 ,(2006) , 10.1177/1533317506289277
Xiao-Hong Li, Jia-Zhao Xie, Xia Jiang, Bing-Ling Lv, Xiang-Shu Cheng, Lai-Ling Du, Jia-Yu Zhang, Jian-Zhi Wang, Xin-Wen Zhou, Methylglyoxal Induces Tau Hyperphosphorylation via Promoting AGEs Formation NeuroMolecular Medicine. ,vol. 14, pp. 338- 348 ,(2012) , 10.1007/S12017-012-8191-0