作者: Tord Ivarsson , Gudmundur Skarphedinsson , Bernhard Weidle
DOI: 10.1016/B978-0-12-811427-8.00009-5
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摘要: Abstract Drug treatment in pediatric OCD has been used for close to 40 years, and the evidence efficacy of serotonin reuptake inhibiting (SRI) drugs that accumulated is substantial. Starting out with placebo-controlled studies it was established patients on SRI (e.g., clomipramine, sertraline, fluoxetine, or fluvoxamine) did decrease symptoms a moderate effect size. However, direct head-to-head comparisons CBT superior more robust across different comparisons. For example, does combination SSRI work well nonresponders, while sertraline do as nonresponders (in trial average duration) not enhance good CBT. We argue should be first-line reserved those who respond expertly delivered possibly extended (i.e., 16–24 sessions). The teams working consider if pharmacological may needed comorbid problems interfere ADHD, severe aggression, etc.)