Synthesis and biological properties of 1,8‐naphthalimidebutylamines. Serotonin 5‐HT1A and 5‐HT7 binding data and pass‐assisted search
作者： Piotr Kowalski , Teresa Kowalska , Andrzej J. Bojarski , Beata Duszyńska
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摘要: Syntheses of the N-substituted butyl derivatives 1,8-naphthalimide (1-8), containing various arylpiperazines, tetrahydroisoquinoline and methylhomopiperazine moieties attached at 4-position chain have been described. Biological activities were evaluated in vitro for their ability to bind serotonin 5-HT1A 5-HT7 receptors. Due structural similarity 1-8 psychotropic agents, pharmacological properties target compounds predicted using PASS program.
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