Experimental Freeze-Dried Microarterial Allografts in Rabbits

摘要: • Arterial allografts, 3.5 cm in length, were freeze-dried and placed into the femoral arteries of 20 female rabbits (16 experimental subjects four controls). Immediate patency was 100%. Subjects surgically explored after two months observation. Overall at this time 31% (5/16). A rate 50% (5/10) achieved with size-matched grafts. However, all smaller diameter brachial grafts unsuccessful. Analysis by light microscopy as well transmission scanning electron demonstrated intimal hyperplasia, which more prominent nonpatent There no evidence a cellular immune response to host. The use postoperative anticoagulants future studies may improve rates potential clinical applicability promising microvascular technique. ( Arch Otolaryngol Head Neck Surg 1987;113:953-958)