Bioorthogonal chemistry for 68Ga radiolabelling of DOTA‐containing compounds

摘要: Copper-catalysed 'click' chemistry is a highly utilised technique for radiolabelling small molecules and peptides imaging applications. The usefulness of these reactions falls short, however, when metal catalysis not practically viable route; such as using chelates radioligands. Here, we describe method carrying out 'click-type' radiochemistry in the presence DOTA chelates, by combining (68) Ga techniques with well-established bioorthogonal reactions, which do rely upon catalysis.