Effects of Inhaled Corticosteroids on Cough Threshold in Patients with Bronchial Asthma

摘要: In asthmatic subjects cough can be related to the degree of airway inflammation. The aim this study was evaluate effect treatment with high dose inhaled beclomethasone dipropionate (BDP) on threshold in subjects. Cough capsaicin (one breath 10−8−10−4M solution) and citric acid 10−4−1 M), expressed as provocative concentration two (PC2) four coughs (PC4), measured 16 normal 36 After baseline evaluation, were randomized groups: (a) Group A, n=20: treated salbutamol (200 μg t.i.d.) plus BDP (500 t.i.d.); (b) B, n=16: placebo same doses. 1 month, clinical functional evaluation repeated. treatment, asthmatics group A showed a significant improvement PC4citric acid, total symptom scores, PD20FEV1methacholine. caused no symptoms, PD20FEV1methacoline threshold. addition, not different between and, asthmatics, did correlate These data confirm that asthma partially