Controlled trials with four per cent cromolyn spray in seasonal allergic rhinitis

摘要: Summary Thirty-two patients with seasonal allergic rhinitis due to weed pollen were treated beginning prior the season of 1974 either 4% cromolyn sodium or placebo nasal spray. The followed on treatment symptom diary cards and bi-weekly physician examinations for a period 10 weeks. Radioallergosorbent (RAST) titres major weeds in Denver area (ragweed, Russian thistle, sage) determined before season, one three months after season. There was no significant difference scores between sodium- placebo-treated groups, nor objective evidence by suggest differences two groups. Significant favor cromolyn-treated group noted amount antihistamines taken symptomatic relief during pollenating suggesting some protective effect drug. clinical significance this finding is not clear. Selecting high baseline RAST more did alter results study. In second double-blind study twenty-two reporting allergy clinic randomly assigned receive spray through season. There groups use asymptomatic relief.