Molecular mechanisms of neuronal polarity

摘要: Neurons are one of the most highly polarized cells known and comprised two structurally functionally distinct parts, an axon dendrites. The specification is thought to depend on its length relative other minor processes, which called immature neurites. Elongation neurites necessary for specification. We previously showed that collapsin response mediator protein-2 (CRMP-2) critical specifying axon/dendrite fate, possibly by promoting neurite elongation via microtubule assembly. Here, we glycogen synthase kinase-3beta (GSK-3beta) phosphorylated CRMP-2 at Thr-514 inactivated it. expression nonphosphorylated form or inhibition GSK-3beta induced formation multiple axons in hippocampal neurons. constitutively active impaired neuronal polarization, whereas counteracted inhibitory effects GSK-3beta, indicating regulates polarity through phosphorylation CRMP-2. here reviewed molecular mechanisms formation.