Epstein–Barr virus associated peri-implantitis: a split-mouth study

摘要: Herpesviral–bacterial synergism may play a potential role in periodontitis and peri-implantitis (PI) etiopathogenesis. PI lesions can worsen depending on specific microbial challenge host susceptibility. This cross-sectional split-mouth study aimed to substantiate herpesviral–bacterial co-infection patients assess associations with periodontopathogen salivary contamination. PCR-based identification was performed 23 presenting contralateral healthy implants, compared unstimulated whole saliva. Clinical evaluation included probing depths, bleeding probing, suppuration. Radiographs were assessed for the presence of lamina dura bone loss. Three sample sites per patient tested: lesions, implant sulci, Quantitative PCR evaluated Epstein–Barr virus (EBV) cytomegalovirus (CMV) copy counts. Significance group comparisons binary-dependent variables, within-subjects designs, determined by McNemar's chi-square test. Risk analysis through odds ratios (OR). 14.2 (P = 0.001; 95 % confidence interval [CI], 1.6–124.1) 3 times (P = 0.03; CI, 0.7–11.9) more likely harbor EBV than implants saliva, respectively. positive predictive value 90 %. associated absence higher proportions. Saliva sampling showed high agreement bacterial detection (89–100 % rate) but not (44.4 %). The OR harboring Treponema denticola or Tannerella forsythia 6.79 (P = 0.007; 1.8–25.0) 3.3 (P < 0.0001; 0.3–34.3) 5.6 be contaminated Prevotella nigrescens peri-implant sulci (P = 0.002). 1.92 (P = 0.04). is candidate useful predicting peri-implantitis-specific infection CMV. favor ongoing disease exacerbate its progression. explain non-responsive treatment PI. Peri-implantitis individuals benefit from antiviral therapy.