Influence of FcRn binding properties on the gastrointestinal absorption and exposure profile of Fc molecules.

摘要: The neonatal Fc receptor (FcRn) represents a transport system with the potential to facilitate absorption of biologics across gastrointestinal barrier. How interact FcRn enable their absorption, and how these interactions might be optimized in biological therapeutic are not well understood. Thus, we studied molecules from intestine using three IgG4-derived variants different, pH-dependent binding release profiles. Using several different intestinal models, consistently observed that affinity correlated transcytosis. Our findings support targeting highlight additional strategic considerations for future work.