Safety and immunogenicity of Haemophilus influenzae vaccine (tetanus toxoid conjugate) administered concurrently or combined with diphtheria and tetanus toxoids, pertussis vaccine and inactivated poliomyelitis vaccine to healthy infants at two, four and six months of age

摘要: The safety and immunogenicity of Haemophilus influenzae vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed the same syringe with diphtheria tetanus toxoids, pertussis inactivated poliomyelitis were assessed 439 infants at 2, 4 6 months age. proportions local redness, tenderness swelling combined groups 18% vs. 11% (P = 0.01 IU/ml 99.5 99.1% infants, agglutinin titers > 64 92.4%, anti-polyribosylribitol phosphate 0.15 microgram/ml 93.8% 1.0 75% polio-neutralizing 8 98% infants. However, antibody concentrations to PRP-T, some antigens significantly lower after than injections DPT/diphtheria PRP-T. clinical significance these differences is not known, but interactions observed among components pentavalent may be concern because they might influence persistence until fourth dose administered.