Patterns of anthracycline retention modulation in human tumor cells.

摘要: Laser excitation of cellular doxorubicin and daunomycin content (with or without incubation in the presence efflux blockers such as phenothiazines verapamil) was studied cells from leukemic peripheral blood, bone marrow aspirates, ascites pleural fluid solid tumor patients. Selected examples are presented to show that heterogeneity anthracycline retention well sensitivity modulations is seen human cells. Several subpopulations differing their anthracyclines modulators were seen. In serial samples patients (pre- post-treatment with anthra-cycline-containing protocols), initial drug andsensitivity followed by lack insensitivity modulators. The present study shows view variables encountered drug-retention characteristics modulators, one needs screen before recommending use any particular transport modulator enhance drug-resistant