Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes
作者： W. A. Haseltine , R. Block
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摘要: Abstract The nucleotides ppGpp and pppGpp accumulate when wild-type, but not rel-, strains of Escherichia coli are starved for required amino acids. These compounds synthesized on ribosomes, in the presence product rel gene, from GDP GTP; ATP is used as phosphate donor. The signal making these an uncharged tRNA ribosomal acceptor site. accumulated if ribosomes actively engaged protein synthesis.
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