Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.

作者: T Chiba , M Yamada , J Sasabe , K Terashita , M Shimoda

DOI: 10.1038/MP.2008.105

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摘要: … levels in hippocampal neurons biochemically, we collected p75 neurotrophin receptor (p75 NTR)-positive (p75 + ) neurons in the hippocampi 26 by MACS and performed specific two-…

参考文章(60)
De-Hua Chui, Hiroshi Tanahashi, Kazuharu Ozawa, Sachiya Ikeda, Frédéric Checler, Otoya Ueda, Hiroshi Suzuki, Wataru Araki, Haruhisa Inoue, Keiro Shirotani, Keikichi Takahashi, Ferenc Gallyas, Takeshi Tabira, Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation Nature Medicine. ,vol. 5, pp. 560- 564 ,(1999) , 10.1038/8438
Yingying Le, Wanghua Gong, H. Lee Tiffany, Alexei Tumanov, Sergei Nedospasov, Weiping Shen, Nancy M. Dunlop, Ji-Liang Gao, Philip M. Murphy, Joost J. Oppenheim, Ji Ming Wang, Amyloid β42 Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1 The Journal of Neuroscience. ,vol. 21, ,(2001) , 10.1523/JNEUROSCI.21-02-J0003.2001
Jennifer L Berkeley, Allan I Levey, Muscarinic activation of mitogen-activated protein kinase in PC12 cells. Journal of Neurochemistry. ,vol. 75, pp. 487- 493 ,(2002) , 10.1046/J.1471-4159.2000.0750487.X
E. D. Roberson, K. Scearce-Levie, J. J. Palop, F. Yan, I. H. Cheng, T. Wu, H. Gerstein, G.-Q. Yu, L. Mucke, Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. ,vol. 316, pp. 750- 754 ,(2007) , 10.1126/SCIENCE.1141736
Rebecca J. Griffin, Suzanne Timmons, Rosemary O’Connor, Rivka Ravid, Cora O’Neill, Aileen M. Moloney, Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling Neurobiology of Aging. ,vol. 31, pp. 224- 243 ,(2010) , 10.1016/J.NEUROBIOLAGING.2008.04.002
Antonella Caccamo, Salvatore Oddo, Lauren M. Billings, Kim N. Green, Hilda Martinez-Coria, Abraham Fisher, Frank M. LaFerla, M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice Neuron. ,vol. 49, pp. 671- 682 ,(2006) , 10.1016/J.NEURON.2006.01.020
Gabriela Krejcova, Jiri Patocka, Jirina Slaninova, Effect of humanin analogues on experimentally induced impairment of spatial memory in rats. Journal of Peptide Science. ,vol. 10, pp. 636- 639 ,(2004) , 10.1002/PSC.569
Christian Haass, Dennis J. Selkoe, Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide Nature Reviews Molecular Cell Biology. ,vol. 8, pp. 101- 112 ,(2007) , 10.1038/NRM2101
Yuichi Hashimoto, Yuka Kaneko, Emi Tsukamoto, Harald Frankowski, Keisuke Kouyama, Yoshiko Kita, Takako Niikura, Sadakazu Aiso, Dale E. Bredesen, Masaaki Matsuoka, Ikuo Nishimoto, Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD Journal of Neurochemistry. ,vol. 90, pp. 549- 558 ,(2004) , 10.1111/J.1471-4159.2004.02513.X