Synthesis and biological activities of ferulic acid derivatives.

摘要: Three types of ferulic acid derivatives (feruloylaminoacid benzyl or methyl esters, feruloylaminoacids, and 4-0-[N-(carbobenzyloxy)-aminoacyl] acid) were synthesized by introduction amino acids at different sites their platelet aggregation (PA)-inhibitory, tyrosinase-inhibitory, angiotensin converting enzyme (ACE)-inhibitory, superoxide dismutase (SOD)-like activities evaluated. PA, one the mechanisms involved in repair blood vessel injury, is related to diseases such as thrombosis. Developing a compound capable inhibiting PA may thus provide therapeutic tool. From results study, particularly case 4-0-[N-(carbobenzyloxy) aminoacyl] (amino components: isoleucine, proline), inhibition collagen-induced was maintained same level with acid, but stronger dissociation ADP-induced detected. In other words, these compounds not only prevent thrombosis also dissolve thrombi. Further, tyrosinase-inhibitory activity found scavenge effectively acid. Since they are more hydrophobic, be efficacious cosmetic ingredients. Finally, feruloyl-Phe-Ala-Pro-OH had strong ACE inhibitory (IC50 = 1.5 microM) lacking itself.