The Curative Effect of Berberine Nanoparticles and Cisplatin Combination Therapies Against Hepatocarcinogenesis-Induced By N-Nitroso-Diethylamine In Male Rat

摘要: This study aimed to investigate whether berberine nanoparticles (BBR-NPs) and/or cisplatin supplementation could prevent hepatocarcinogenesis-induced by N-nitroso-diethylamine (DENA) in male rats. Male Wistar albino rats were divided into five groups; Group 1: Control; 2: DENA-CCl4; 3: DENA-CCl4+Cisplatin; 4: DENA-CCl4+BBR-NPs; 5: DENA-CCl4+Cisplatin+BBR-NPs. DENA-CCl4 significantly increase AST, ALT, ALP, LDH, GGT, AFP activities and total bilirubin, while, 5, NT,  protein albumin decreased. treatment caused increment MDA levels reduction SOD, CAT, GPx GSH liver tissues. Moreover, the gene expression of ADAM17 TNF-a however,  P53 was declined. In addition, severe histopathological lesions tissue. Interestingly, administration alone or combination with improves hepatocarcinogenesis induced on physiological, biochemical, molecular histological decreasing oxidative stress preserving ADAM17, TNF-I P53. The present findings suggest that BBR-NPs might offer a promising strategy for prevention cancer.