Cyclodextrin enhanced antimicrobial efficiency of triclosan against Streptococcus mutans

摘要: The dental plaque control is an important step in prevention and treatment of diseases, such as caries, gingivitis peridontitis. This might be achieved by regular brushing supported the use a suitable antimicrobial agent, triclosan. Although triclosan shows potent activity against Streptoccocus mutans, S. sanguis, salivarius Actinoyicetes species, which have major role aetiology conditions, therapeutical efficiency this compound significantly impaired its practical insolubility water. aim work was to improve aqueous solubility, consequently activity, through drug complexation with parent β-cyclodextrin (βCD) water-soluble polymeric derivative (PβCD). particular goal monitor effect cyclodextrin on both or formulated situ cross-linking mucoadhesive buccal patch, using mutans ATCC 33402 model for evaluation therapeutic efficacy. Triclosan complexes βCD PβCD, prepared co-grinding high energy vibrational micromill, increased solubility simulated saliva 9.6 21 times, respectively. When monitored function time, superior that pure compound, 24 h reduced number bacteria only 2 log10CFUmL-1. In same time completely eradicated TR/PβCD first 4 TR/βCD, agreement their different solubilities. Similar effects were observed when drug, alone loaded into patches low methoxy amidated pectin (AMP) carbomer (CAR). Preliminary studies showed 80:20 w/w AMP:CAR mixture swelling properties, erosion (20.6%), good mucoadhesion. vitro dissolution clearly demonstrated performance patch formulations complexes. fact, formulation inhibition zone 51.0±1.3 mm, comparable ampicilin (48.0±5.3 mm), demonstrating potential developed eradication mutans.