Melanocyte Distribution and Function in Human Skin

摘要: Catalytic entities involved in melanin synthesis (including tyrosinase [TYR], tyrosinase-related protein 1 [TYRP1], and dopachrome tautomerase [DCT]) structural proteins important to the integrity of melanosomes GP100/Pmel17) play active roles maintenance function structure those organelles produced by melanocytes. Constitutive skin pigmentation is regulated a number distinct factors melanocyte dendricity, transport dendrites, transfer keratinocytes their subsequent distribution) can be affected paracrine (from neighboring fibroblasts) environment, including ultraviolet (UV) radiation, that regulate proliferation function. Because UV inherently associated with photocarcinogenesis skin, melanoma, we discuss density function, content distribution, DNA damage (measured 6,4-phytoproducts [64PP] cyclobutane pyrimidine dimers [CPD]) apoptosis terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling [TUNEL] staining) response three different types skin. In sum, UV-induced lower epidermis not effectively prevented light/fair seen light after low doses UV. These observations suggest combination decreased more efficient removal UV-damaged cells plays an role darker