Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies

摘要: Purpose: To compare the performance of standard lag time model (LAG model) with an analytical solution transit compartment (TRANSIT in evaluation four pharmacokinetic studies different compounds. Methods: The population analyses were performed using NONMEM on concentration–time data glibenclamide, furosemide, amiloride, and moxonidine. In TRANSIT model, optimal number compartments was estimated from data. This based for change drug concentration arising a series same first-order transfer rate between each compartment. Goodness-of-fit assessed by decrease objective function value (OFV) inspection diagnostic graphs. Results: With OFV significantly lower goodness-of-fit markedly improved absorption phase compared LAG all drugs. parameter estimates related to differed two models while disposition parameters similar. Conclusion: Based these results, is attractive alternative modeling delay, especially when poorly describes or numerically unstable.