Prenatal maternal immune activation and brain development with relevance to psychiatric disorders.
作者： Gustavo Scola , Angela Duong
DOI: 10.1016/J.NEUROSCIENCE.2017.01.033
关键词:
摘要: Growing evidence from epidemiological studies strongly suggests maternal infection as a risk factor for psychiatric disorders including bipolar disorder, schizophrenia, and autism. Animal support this association demonstrate that immune activation (MIA) changes brain morphology inflammatory cytokines in the adult offspring. Evidence is also demonstrated human post-mortem peripheral blood subjects with disorders. This perspective briefly highlights convincing epidemiological, preclinical pathological to role of MIA major A better understanding link between development will lead novel immunomodulatory interventions individuals at
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