Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines

摘要: Compounds of the formula: wherein: R a is iodo, (C 1 -C 4 )hydroxyalkyl, benzyloxy, OCF 3 , SCF SO H, 2 F, NR where hydrogen or )alkyl and hydrogen, )alkyl, phenyl, phenyl; group formula wherein 5 6 are each independently, ) perfluoroalkyl, 7 halo, hydroxy, )alkoxy, N(R )alkyl; n an integer 1-4; b each, mercapto, )thioalkyl, nitro, cyano, methylenedioxy, ethylenedioxy, COCH CF COOH, phenyl substituted by selected from alkoxy, amino, F H as defined above; benzyloxy on portion pharmaceutically acceptable salt thereof; methods for treatment cancer allergic reactions.