Tandem Esterification/1,4-Addition-Type Friedel–Crafts Alkylation Reactions of Phenols/Naphthols with Olefinic Thioazlactones: Access to Functionalized 1,2-Dihydrobenzo[f]chromen-3-ones and 3,4-Dihydrochromen-2-ones
作者： Azim Ziyaei Halimehjani , Maryam Khoshdoun
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摘要: An efficient approach for the synthesis of novel alkyl 2,3-dihydro-3-oxo-1-aryl-1H-benzo[f]chromen-2-ylcarbamodithioates and 3,4-dihydro-2-oxo-4-aryl-2H-chromen-3-ylcarbamodithioates from 2-(alkylthio)thioazlactones (thioazlactones) phenols or naphthols catalyzed by PTSA was developed. The reaction proceeds via a domino esterification/intramolecular 1,4-addition-type Friedel–Crafts alkylation to afford interesting complex molecules simple procedure with high yields diastereoselectivity. X-ray analysis carried out firmly establish stereochemistry products.
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