Three-dimensional finite element modeling of skeletal muscle using a two-domain approach: linked fiber-matrix mesh model.

摘要: In previous applications of the finite element method in modeling mechanical behavior skeletal muscle, passive and active properties muscle tissue were lumped one element. Although this approach yields increased understanding effects force transmission, it does not support an assessment interaction between intracellular structures extracellular matrix. present study, is considered two domains: (1) domain (2) matrix domain. The domains are represented by separate meshes that linked elastically to account for trans-sarcolemmal attachments fibers’ cytoskeleton With a model developed, which allows transmission these with possibility investigating their as well role systems. The applied show significance myofascial possible consequences due any missing link within connections such found muscular dystrophies. This realized making links highly compliant at selected intramuscular locations. results indicate sustaining its physiological condition. It shown if there inadequate linking matrix, myofibers become deformed beyond limits lacking impairment pathway leads calculation drop located more towards center model, pronounced. These non-myotendinous pathways.