2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

摘要: In 1991, the American College of Chest Physicians (ACCP) and Society Critical Care Medicine (SCCM) convened a "Consensus Conference," goals which were to "provide conceptual practical framework define systemic inflammatory response infection, is progressive injurious process that falls under generalized term 'sepsis' includes sepsis-associated organ dysfunction as well. The general definitions introduced result conference have been widely used in practice, served foundation for inclusion criteria numerous clinical trials therapeutic interventions. Nevertheless, there has an impetus from experts field modify these reflect our current understanding pathophysiology syndromes. Several North European intensive care societies agreed revisit sepsis related conditions. This was sponsored by (SCCM), Intensive (ESICM), (ACCP), Thoracic (ATS), Surgical Infection (SIS). 29 participants attended Europe America. advance conference, subgroups formed evaluate following areas: signs symptoms sepsis, cell markers, cytokines, microbiologic data, coagulation parameters.. present manuscript serves final report 2001 International Sepsis Definitions Conference. 1. Current concepts severe septic shock remain useful clinicians researchers. 2. These do not allow precise staging or prognostication host infection. 3. While SIRS remains concept, diagnostic published 1992 are overly sensitive non-specific. 4. An expanded list may better 6. PIRO, hypothetical model presented, which, future, characterize syndrome on basis predisposing factors premorbid conditions, nature underlying characteristics response, extent resultant dysfunction.