Osteoarthritis biomarkers: year in review.

摘要: Summary Objective To summarise important findings from biomarker studies relevant to osteoarthritis (OA), published between April 2016 and March 2017; consider these in the context of new discoveries technologies, clinical scientific need OA. Design Studies were selected by PubMed search, conducted 01/04/2016 01/03/2017. MeSH terms [biomarker] AND [OA] used; search was restricted Human, English language Full Text Available publications, which yielded 50 eligible publications. Any considered, including non-proteins other measurements. Results Three main areas are overviewed: 1) examining highly validated biomarkers, FNIH OA Biomarkers Consortium elsewhere, particularly their ongoing application validation. Control reference intervals, work on predictive validity longitudinal prognostic value biomarkers large cohorts reviewed. 2) Novel relating inflammation discussed, complement, performance markers so-called ‘cold inflammation' results trials biomarkers. 3) Discovery studies, whole blood RNA, proteomics metabolomics reviewed, with an emphasis technologies. Conclusions Discovery, characterisation qualification various is ongoing; several novel protein non-protein candidate have been reported this year. provide us opportunity better diagnose stratify disease, via established panels or discovery approaches. Improving quality sampling testing, measuring numbers simultaneously would seem likely identify clinically applicable still much needed disease.