Carbon Nanotubes: Nanotoxicity Testing and Bioapplications

摘要: With the growing use of nanomaterials in bioapplications, nanotoxicity new has become a safety concern when used various applications. In this chapter, technical developments on carbon nanotubes are described including historical account, experimental models and potential bioapplications. Carbon nanotube (CNT) materials display superior properties electric current carrying capacity, thermal conductivity, stability. Due to unique CNT structure with high-aspect ratio, may show unusual toxicity complicate its safe target tissue. To test CNT, we describe set protocols prior knowledgebased physical chemical characteristics develop 3-dimensional vitro intact skin, 3D model human airway using co-culture normal bronchial epithelial cells fi broblasts. The served as tool health risk assessment CNTs respiratory systems. functionality at different concentrations model, multiwalled production nitric oxide (NO) cell viability infl ammatory marker; mitochondrial activity (MTT assay) cytotoxic response layers; transepithelial electrical resistance (TER) measured changes physiological function. Cytoxicity responses were dependent size, mass, shape, viable vivo tests conducted evaluate 98 Nanomaterials Drug Delivery engineered CNTs. We monitored transport across perturbation during exposure mechanisms CNTs’ closely related their structure, functional group, surface charge molecule. established nanoscale fullerenes