The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes
作者： Katherine I. Swenson , Kevin M. Farrell , Joan V. Ruderman
DOI: 10.1016/0092-8674(86)90801-9
关键词:
摘要: Fertilized clam embryos synthesize several new cell-cycle-related proteins. The cloned cDNA and derived amino acid sequences of one these, cyclin A, are presented here. Immunoblots with an anti-cyclin A antibody reveal that is undetectable in oocytes, appears within 15 min fertilization, destroyed near the end each meiosis mitosis. We directly tested ability to induce M phase by injecting SP6 mRNA into Xenopus which arrested at G2/M border first meiosis. injected was translated, result oocytes entered These findings indicate rise plays a direct natural role driving cells phase.
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