Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.

摘要: Truncated and mutant forms ofp53 affect life span in Drosophila, nematodes mice, however the role of wild-type p53 aging remains unclear. Here conditional over-expression both transgenes indicated that, adult flies, limits females but favors males. In contrast, during larval development, moderate produced male female adults with increased span. Mutations endogenous gene also had sex-specific effects on under control stress conditions: null mutation females, smaller, more variable These developmental stage-specific are consistent a sexual antagonistic pleiotropy model.