Single flexible sigmoidoscopy screening to prevent colorectal cancer: baseline findings of a UK multicentre randomised trial.

摘要: Summary Background This randomised controlled trial is examining the hypothesis that a single flexible sigmoidoscopy screening offered at around age 60 years can lower incidence and mortality of colorectal cancer. We report here on acceptability, safety, feasibility, yield. Methods Men women aged 55–64 years, in 14 UK centres, who responded to mailed questionnaire they would attend for if invited, were randomly assigned or control (ratio one two). The group was not contacted. Small polyps removed during screening, colonoscopy undertaken high-risk (three more adenomas, size 1 cm greater, villous, severely dysplastic, malignant) found. Findings Of 354 262 people asked about their interest having 194 726 (55%) positively, 170 432 eligible individuals randomised. Attendance among those 71% (40 674 57 254). 2131 (5%) classified as highrisk referred colonoscopy; 38 525 with no only low-risk detected discharged. Distal adenomas 4931 (12·1%) distal cancer 131 (0·3%). Proximal 386 (18·8% undergoing colonoscopy) proximal nine cases (0·4%). 62% cancers Dukes' stage A locally excised. There perforation after four colonoscopy. An average 48 screened, two three referrals generated, per centre each week. Interpretation Our regimen acceptable, feasible, safe. prevalence neoplasia high, referral rates 5% are acceptable.