INVESTIGATION OF CARDIAC ELECTROPHYSIOLOGY IN HUMAN VENTRICULAR TISSUE
作者： Kathleen Brownson
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摘要: OF THESIS INVESTIGATION CARDIAC ELECTROPHYSIOLOGY IN HUMAN VENTRICULAR TISSUE Individuals with cardiomyopathy are at higher risk to die from sudden cardiac arrest than those non-failing (NF) hearts. This study examined the differences in electrical properties of failing and NF human hearts terms memory through explicit control diastolic intervals a sinusoidal fashion, restitution action potential duration (APD) standard dynamic pacing protocols, maximum rate depolarization APD alternans. Recordings transmembrane potentials were made tissues extracted patients heart failure one donor heart. Computational simulations performed using O’Hara Rudy model for generating surrogates data. Significant seen between left ventricular (LV) tissue LV tilt, measures area thickness during 400ms protocol. Minimum delay was also significantly 150ms Failing showed slope prolonged AP which is consistent previous studies hypothesized contribute increased susceptibility unstable further explored how disease alters functioning why these arrhythmia.
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