Spontaneous immunity against Bcl-xL in cancer patients.

摘要: It is well-established that peptide epitopes derived from human tumor-associated Ags can be recognized by CTL in the context of MHC molecule. However, vast majority described are not vital for survival and growth tumor cells, immunoselection Ag-loss variants during immunotherapy has been demonstrated several cases. Malfunctions death pathways observed cancers often due to overexpression antiapoptotic proteins Bcl-2 protein family, i.e., Bcl-2, Mcl-1, Bcl-xL. These implicated cancer development, progression, drug resistance. The general members family fact down-regulation or loss expression these as a means immune escape would impair sustained makes them very attractive targets anticancer immunotherapy. Recently, we identified spontaneous T cell responses against Bcl-2- Mcl-1-derived peptides patients suffering different origin. In this study, demonstrate Bcl-xL target recognition patients. Thus, describe HLA-A2-restricted cytotoxic ELISPOT flow cytometry stainings, whereas no were detected any healthy controls. Moreover, Bcl-xL-specific cells HLA-matched cellular apoptosis inhibitors like appear represent feature cancer.