Association Study on IL4, IL13 and IL4RA Polymorphisms in Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population
作者： Mei-Ping Lu , Ruo-Xi Chen , Mei-Lin Wang , Xin-Jie Zhu , Lu-Ping Zhu
DOI: 10.1371/JOURNAL.PONE.0027363
关键词:
摘要: Background The IL4, IL13, and IL4 receptor α chain (IL4RA) genes are candidate for atopic diseases. We hypothesized that the polymorphisms in these associated with persistent allergic rhinitis (PER). Objective To investigate association of potential functional IL4RA PER induced by house dust mites a Chinese population. Methods Using TaqMan method, we genotyped six single nucleotide (SNPs) including C-590T C-1055T Arg130Gln Ile50Val, Ser478Pro Gln551Arg IL4RA, case-control study 265 patients 275 healthy controls. Results We found CT/CC genotypes were significantly decreased risk mite-sensitized [adjusted odds ratio (OR) = 0.64, 95% confidence interval (CI) 0.45–0.92], compared to TT genotype. Furthermore, had lower serum levels total IgE than those genotype (P 0.001). However, there was no significant IL13 (P>0.05). Conclusions Our results suggest polymorphism may contribute susceptibility population.
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Epidemiology of rhinitis: allergic and nonallergic. Clinical allergy and immunology. ,vol. 19, pp. 23- 34 ,(2007) , 10.3109/9781420021172-6
J Bartra, J Sastre, J Montoro, J Mullol, I Dávila, M Ferrer, I Jáuregui, A del Cuvillo, A Valero, Genetic aspects of allergic rhinitis. Journal of Investigational Allergology and Clinical Immunology. pp. 25- 31 ,(2009)
Xin Liu, Terri H Beaty, Philipp Deindl, Shau-Ku Huang, Susanne Lau, Christine Sommerfeld, M.Daniele Fallin, W.H.Linda Kao, Ulrich Wahn, Renate Nickel, Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. The Journal of Allergy and Clinical Immunology. ,vol. 113, pp. 489- 495 ,(2004) , 10.1016/J.JACI.2003.12.037
K. Yabiku, M. Hayashi, I. Komiya, T. Yamada, Y. Kinjo, Y. Ohshiro, T. Kouki, N. Takasu, Polymorphisms of interleukin (IL)‐4 receptor alpha and signal transducer and activator of transcription‐6 (Stat6) are associated with increased IL‐4Rα–Stat6 signalling in lymphocytes and elevated serum IgE in patients with Graves' disease Clinical and Experimental Immunology. ,vol. 148, pp. 425- 431 ,(2007) , 10.1111/J.1365-2249.2007.03366.X
Susanne Kruse, Sandra Braun, Klaus A Deichmann, Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain. Respiratory Research. ,vol. 3, pp. 24- 24 ,(2002) , 10.1186/RR174
Kimberly A. Risma, Ning Wang, Ryan P. Andrews, Christie M. Cunningham, Mark B. Ericksen, Jonathan A. Bernstein, Ranajit Chakraborty, Gurjit K. Khurana Hershey, V75R576 IL-4 Receptor α Is Associated with Allergic Asthma and Enhanced IL-4 Receptor Function Journal of Immunology. ,vol. 169, pp. 1604- 1610 ,(2002) , 10.4049/JIMMUNOL.169.3.1604
Penelope E. Graves, Michael Kabesch, Marilyn Halonen, Catharine J. Holberg, Mauro Baldini, Christian Fritzsch, Stephan K. Weiland, Robert P. Erickson, Erika von Mutius, Fernando D. Martinez, A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children The Journal of Allergy and Clinical Immunology. ,vol. 105, pp. 506- 513 ,(2000) , 10.1067/MAI.2000.104940
L. J. ROSENWASSER, D. J. KLEMM, J. K. DRESBACK, H. INAMURA, J. J. MASCALI, M. KLINNERT, L. BORISH, Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy Clinical & Experimental Allergy. ,vol. 25, pp. 74- 78 ,(1995) , 10.1111/J.1365-2222.1995.TB00428.X
S. Black, A. S. Teixeira, A. X. W. Loh, L. Vinall, J. W. Holloway, R. Hardy, D. M. Swallow, Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort. Allergy. ,vol. 64, pp. 1172- 1178 ,(2009) , 10.1111/J.1398-9995.2009.01988.X
Hiroyuki Nakamura, Kiyoshi Miyagawa, Keiki Ogino, Tomohiko Endo, Toru Imai, Kotaro Ozasa, Yutaka Motohashi, Ichiyo Matsuzaki, Shinichiro Sasahara, Kotaro Hatta, Akira Eboshida, High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor α-chain in Japanese cedar pollinosis The Journal of Allergy and Clinical Immunology. ,vol. 112, pp. 1127- 1131 ,(2003) , 10.1016/J.JACI.2003.08.051