Bioactivity and cytotoxicity of glass and glass–ceramics based on the 3CaO·P2O5–SiO2–MgO system

摘要: The mechanical strength of bioactive glasses can be improved by controlled crystallization, turning its use as bulk bone implants viable. However, crystallization may affect the bioactivity material. aim this study was to develop glass-ceramics nominal composition (wt%) 52.75(3CaO·P₂O₅)-30SiO₂-17.25MgO, with different crystallized fractions and evaluate their in vitro cytotoxicity bioactivity. Specimens were heat-treated at 700, 775 975 °C, for 4 h. major crystalline phase identified whitlockite, an Mg-substituted tricalcium phosphate. evaluation carried out neutral red uptake methodology. Ionic exchanges simulated body fluid SBF-K9 acellular solution during tests highlight differences terms chemical reactivity between glass glass-ceramics. effect crystallinity on rates hydroxycarbonate apatite (HCA) formation followed Fourier transformed infrared spectroscopy. Although all considered bioactive, glass-ceramic °C (V775-4) presented most interesting result, because onset HCA is about 24 h after 7 days layer dominates completely spectrum. This occurs probably due presence whitlockite (3(Ca,Mg)O·P₂O₅). All samples not cytotoxic.