The Role of IL-2 in the Development and Peripheral Homeostasis of Naturally Occurring CD4 + CD25 + Foxp3 + Regulatory T Cells

摘要: Naturally occurring CD4+CD25+Foxp3+ regulatory T cells (Treg) actively suppress autoreactive that escape negative selection in the thymus, preventing a wide variety of autoimmune diseases. Along with Foxp3, high affinity IL-2R represents one better characterized molecules Treg cells. Current data support models where IL-2/IL-2R interaction, primarily through STAT5 activation, controls cell development thymus and their growth maintenance peripheral immune tissues. The recent link between signaling upregulation Foxp3 also raises possibility IL-2 is important for suppressive function. Other issues concern cellular source novel aspects potentially regulate limit to Although essential, other cytokines within outside γc family likely contribute production.