Coordinated Action of N-CAM, N-cadherin, EphA4, and ephrinB2 Translates Genetic Prepatterns into Structure during Somitogenesis in Chick
作者： James A. Glazier , Ying Zhang , Maciej Swat , Benjamin Zaitlen , Santiago Schnell
DOI: 10.1016/S0070-2153(07)81007-6
关键词:
摘要: During gastrulation in vertebrates, mesenchymal cells at the anterior end of presomitic mesoderm (PSM) periodically compact, transiently epithelialize and detach from posterior PSM to form somites. In prevailing clock-and-wavefront model somitogenesis, periodic gene expression, particularly Notch Wnt, interacts with an FGF8-based thresholding mechanism determine cell fates. However, this does not explain how determination subsequent differentiation translates into somite morphology. paper, we use computer simulations chick somitogenesis show that experimentally-observed temporal spatial patterns adhesive N-CAM N-cadherin repulsive EphA4-ephrinB2 pairs suffice reproduce complex dynamic morphological changes wild-type (-/-) chick, including intersomitic separation, boundary-shape evolution sorting misdifferentiated across compartment boundaries. Since different models yield same, experimentally-observed, distribution adhesion repulsion molecules, patterning is independent details mechanism.
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