The Induction of Apoptosis by Shiga Toxins and Ricin

摘要: Shiga toxins and ricin are ribosome-inactivating proteins which share the property of inhibiting protein synthesis by catalytic inactivation eukaryotic ribosomes. There is now abundant evidence that induce apoptosis in epithelial, endothelial, lymphoid myeloid cells vitro, multiple organs animals when administered these toxins. Many studies suggest inhibition induction mediated may be dissociated. In some cells, non-enzymatic toxin components (Shiga B-subunits, B-chain) appear capable inducing apoptosis. The activating both extrinsic or death receptor-mediated intrinsic mitochondrial-mediated pathways induction. Although have been shown to several cell stress response pathways, precise signaling mechanisms remain fully characterized. This chapter provides an overview describing toxin- ricin-induced reviews through ribotoxic unfolded involved types.