Inflammatory Cells in Allergic Disease

摘要: Allergic diseases (evoked totally, or in part, by IgE-mediated mechanisms) affect many organs and tissues, but particular the upper lower respiratory tract, eyes, gastro-intestinal tract skin. The rapid release of mast cell-associated mediators probably accounts almost entirely for clinical manifestations immediate hypersensitivity, i.e. rhinorrhoea, nasal blockage, sneezing, wheeze, pruritus, abdominal discomfort diarrhoea. After a single exposure to allergen these symptoms are self-limiting usually subside spontaneously (Figure 8.1). With repeated exposure, prominent local inflammatory response develops. This is associated with more prolonged protracted such as bronchial irritability hyperresponsiveness, permanent congestion, indurated skin lesions chronic mucoid It should be borne mind that mucus hypersecretion characteristic feature inflammation at all mucosal surfaces.