Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community

摘要: Background Anaphylaxis is a serious hypersensitivity reaction that rapid in onset and may cause death. Adrenaline (epinephrine) auto-injectors are recommended as the initial, potentially life-saving treatment of choice for anaphylaxis community, but they not universally available have limitations their use. Objectives To assess effectiveness adrenaline relieving respiratory, cardiovascular, other symptoms during episodes occur community. Search methods We searched Cochrane Central Register Controlled Trials (CENTRAL) (The Library 2012, Issue 1), MEDLINE (Ovid SP) (1950 to January 2012), EMBASE (1980 2012 ), CINAHL (EBSCO host) (1982 AMED (1985 LILACS, (BIREME) ISI Web Science ). We adapted our search terms databases. also websites listing on-going trials: World Health Organization International Clinical Registry Platform, UK Research Network Study Portfolio, meta Trials; contacted pharmaceutical companies who manufacture an attempt locate unpublished material. Selection criteria Randomized quasi-randomized controlled trials comparing auto-injector administration with any control including no intervention, placebo, or adrenergic agonists were eligible inclusion. Data collection analysis Two authors independently assessed articles inclusion. Main results None 1328 studies identified satisfied inclusion criteria. Authors' conclusions Based on this review, we cannot make new recommendations anaphylaxis. Although randomized, double-blind, placebo-controlled clinical high methodological quality necessary define true extent benefits from via auto-injector, such unlikely be performed individuals experiencing because ethical concerns associated randomization placebo. There is, however, need consider which, example, different doses differing devices compared order provide greater clarity dose device choice. Such would practically challenging conduct. In absence appropriate trials, recommend by should still regarded most effective first-line management community. countries where commonly used, it possible conduct compare administered syringe ampoule, two types auto-injector.