Seasonal variations in the rate and capacity of cardiac SR calcium accumulation in a hibernating species.
作者： Darrell D. Belke , Rachel E. Milner , Lawrence C.H. Wang
DOI: 10.1016/0011-2240(91)90042-M
关键词:
摘要: The rate of calcium uptake and the level accumulation was measured in cardiac muscle SR from hibernating nonhibernating Richardson's ground squirrels. In whole heart homogenates, higher (P less than 0.05) animals it active animals. Further purification homogenates into sacroplasmic reticulum (SR) preparations showed that had highest greatest accumulation. These results could not be explained by variations non-SR membrane contaminants nor changes maximal activity or total amount a marker enzyme, Ca(2+)-ATPase. addition ryanodine to medium increased all groups similar amount. It is concluded high isolated vesicles squirrels reflects organelle vivo, ability ryanodine-insensitive population accumulate affected hibernation.
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