Pneumococcal sepsis and nasopharyngeal carriage.

摘要: PURPOSE OF REVIEW Streptococcus pneumoniae (the pneumococcus) remains an important cause of invasive disease including bacteraemia. This review highlights recent findings related to pneumococcal bacteraemia, virulence factors, and multiple colonization, strain competition, biofilm formation, competence. RECENT FINDINGS Countries with no vaccination programmes see vaccine serotypes still prevalent in disease, whereas the emergence nonvaccine nasopharyngeal carriage is seen countries conjugate place. Co-colonizing strains are being uncovered more sensitive methods, may act synergistically or compete each other for survival. Several factors such as iron uptake, quorum signalling luxS gene, involved colonization virulence, discussed. The role sensing molecules formation biofilms explored. SUMMARY Epidemiological data suggest that latest serotype-based vaccines should provide heightened protection, although serotype replacement now seen. Much be elucidated about its biology during when evolution adaptation host take modes (biofilm, intracellular surface adherence mucosal epithelium), whether organisms have attenuated ability colonize nasopharynx remain elucidated.